Description

Buy CJC 1295 with DAC 5mg | High Purity Research Peptide Europe

Welcome to euresearchpeptides.com — your premier European source for high-purity research peptides. Our CJC 1295 with DAC 5mg peptide is a synthetic analogue of growth hormone-releasing hormone (GHRH), designed for advanced laboratory research into growth hormone pathways, anti-aging mechanisms, and metabolic studies. buy CJC 1295 with DAC 5mg online EU

What Is CJC 1295 with DAC?

CJC 1295 with DAC (Drug Affinity Complex) is a 30-amino acid peptide analogue of GHRH that stimulates the release of growth hormone (GH) from the pituitary gland. Unlike standard GHRH peptides, CJC 1295 incorporates a reactive maleimidopropionic acid group that covalently links the peptide to free thiols on circulating plasma proteins, primarily albumin. This conjugation mechanism dramatically extends the peptide’s half-life, making it unique among GHRH analogues for research applications. buy CJC 1295 with DAC 5mg online EU 

The “DAC” component allows the peptide to remain active in the bloodstream significantly longer than non-conjugated peptide-based compounds that are rapidly excreted. This property makes CJC 1295 with DAC particularly valuable for studying sustained GH release patterns, IGF-1 modulation, and long-term metabolic effects in preclinical models. buy CJC 1295 with DAC 5mg online EU

Key identifiers for this research compound:

• CAS Number: 446262-90-4

• Molecular Formula: C165H269N47O46 (varies by salt form)

• Molecular Weight: 3368-3775 Da depending on formulation

This product is strictly for laboratory research use only and not for human consumption.

Chemical Properties & Specifications

Mechanism of Action for Research

CJC 1295 with DAC functions as a potent GHRH analogue with unique pharmacokinetic properties:

Albumin Conjugation: The Drug Affinity Complex contains a maleimidopropionic acid group that forms a covalent bond with free thiols on plasma proteins, primarily albumin. This conjugation renders the peptide effectively undetectable by standard top-down mass spectrometry screening protocols as it becomes a macromolecular protein with undefined molecular weight.

Sustained GH Stimulation: Once conjugated to plasma proteins, CJC 1295 with DAC remains active in the bloodstream and stimulates pulsatile GH release from the anterior pituitary. Research demonstrates dose-dependent increases in GH and IGF-1 levels following subcutaneous administration.

Modified Amino Acid Sequence: The peptide contains specific substitutions that enhance stability and resistance to enzymatic degradation:

• D-Alanine substitution at position 2

• Glutamine for Asparagine at position 8

• Alanine for Glycine at position 15

• Leucine for Methionine at position 27

These modifications, combined with the DAC conjugation, protect the peptide from rapid degradation by dipeptidyl peptidase-IV (DPP-IV), which normally limits GHRH half-life to approximately 7 minutes.

Research Applications

CJC 1295 with DAC is utilized across multiple research domains:

Solubility & Reconstitution Guidelines

CJC 1295 with DAC exhibits good solubility in aqueous solutions.

Recommended Reconstitution Protocol (5mg vial):

Procedure:

1. Allow the lyophilized vial to reach room temperature before opening

2. Inject diluent slowly down the inner wall of the vial

3. Gently swirl or roll the vial until the solution is clear and fully dissolved

4. Do not shake vigorously, as this may degrade the peptide structure

5. Label with date, concentration, and lot number

Storage & Stability

Proper storage is critical for maintaining peptide integrity.

Shelf Life: >2 years when stored properly in lyophilized form at -20°C

Handling Protocols & Safety Information

GHS Hazard Classification:

• Acute toxicity, Oral (Category 4) – H302: Harmful if swallowed

• Acute aquatic toxicity (Category 1) – H400: Very toxic to aquatic life

• Chronic aquatic toxicity (Category 1) – H410: Very toxic to aquatic life with long-lasting effects

Precautionary Measures:

• Wear appropriate personal protective equipment (PPE) including gloves and safety goggles

• Avoid inhalation, contact with eyes and skin

• Use only in areas with appropriate exhaust ventilation

• Do not eat, drink, or smoke when handling this product

• Wash skin thoroughly after handling

• Avoid release to the environment

Quality Standards

At EU Research Peptides, our CJC 1295 with DAC 5mg meets rigorous quality specifications:

• Synthesis: Solid-phase peptide synthesis (SPPS) with Fmoc chemistry

• Purification: HPLC purification to ≥99% purity

• Verification: Mass spectrometry (MS) confirmation of molecular weight

• Quality Control: Each batch includes Certificate of Analysis (COA) with HPLC chromatogram

• Endotoxin Testing: <1.0 EU/mg

• Facility: ISO-classified manufacturing environment

All products are labeled “For Research Use Only” and comply with EU chemical regulations.

👉 Explore our complete catalog of research peptides at our official homepage.

Why Researchers Choose EU Research Peptides

European-Based Operations: Strategically located in the EU for fast, reliable shipping without customs delays.

Premium Quality: Every peptide batch undergoes rigorous third-party testing for purity, stability, and verification.

Research Compliance: Full compliance with EU regulations and chemical safety standards.

Technical Documentation: Comprehensive COAs, MSDS, and reconstitution protocols included with every order.

Competitive Pricing: Volume discounts for research institutions and bulk orders.

Frequently Asked Questions (FAQ)

What is CJC 1295 with DAC?

CJC 1295 with DAC is a 30-amino acid synthetic analogue of growth hormone-releasing hormone (GHRH) that contains a Drug Affinity Complex (DAC). This complex allows the peptide to bind covalently to circulating plasma proteins, primarily albumin, which significantly extends its half-life in research models.

What is the CAS number for CJC 1295 with DAC?

The CAS number is 446262-90-4.

What is the molecular weight of CJC 1295 with DAC?

The molecular weight varies depending on the salt form, ranging from approximately 3368 Da to 3775 Da.

What purity level does EU Research Peptides offer?

Our CJC 1295 with DAC is tested at ≥99% purity by HPLC with mass spectrometry confirmation. Each batch includes a Certificate of Analysis.

What is the peptide sequence?

The sequence is: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 with a Lysine-maleimidopropionyl modification at the C-terminus.

How should I store CJC 1295 with DAC?

Lyophilized peptide should be stored at -20°C or -80°C, protected from light and moisture. After reconstitution, refrigerate at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.

Is CJC 1295 with DAC soluble in water?

Yes, it is soluble in sterile water, bacteriostatic water, and 0.9% sodium chloride solution. Limited solubility in DMSO has also been reported.

What are the primary research applications for this peptide?

CJC 1295 with DAC is studied in anti-aging research, metabolic studies, muscle growth research, wound healing investigations, sleep research, and obesity research models.

What is the DAC component and what does it do?

DAC (Drug Affinity Complex) contains a maleimidopropionic acid group that forms a covalent bond with free thiols on plasma proteins like albumin. This conjugation protects the peptide from rapid enzymatic degradation and renal clearance, dramatically extending its half-life compared to non-conjugated GHRH analogues.

Why was clinical development discontinued?

A Phase 2 clinical trial for HIV-associated visceral obesity (EudraCT: 2005-003797-25) was prematurely ended. A serious adverse event occurred in a volunteer during clinical studies. CJC 1295 with DAC has never received marketing authorization for therapeutic use.

What safety precautions should I take when handling?

Wear appropriate personal protective equipment including gloves and safety goggles. Use in well-ventilated areas. Avoid inhalation, eye contact, and skin contact. Do not eat, drink, or smoke when handling. The compound is harmful if swallowed and very toxic to aquatic life.

Can this peptide be detected in research samples?

Detection is challenging because conjugation to plasma proteins effectively renders CJC 1295 with DAC a macromolecular protein with undefined molecular weight. Specialized immuno-polymerase chain reaction (I-PCR) assays have been developed capable of detecting the peptide-protein conjugate at concentrations down to 0.8 pg/mL.

What is the half-life of CJC 1295 with DAC?

Unlike non-conjugated peptides that are rapidly excreted within minutes, the DAC-mediated albumin conjugation provides significantly extended circulation time. Research indicates sustained activity over days rather than hours.

Does CJC 1295 with DAC preserve GH pulsatility?

Yes, research demonstrates that while CJC 1295 with DAC elevates baseline GH levels, it preserves the pulsatile nature of GH secretion, which is important for the biological activity of the GH/IGF-1 axis.