Description

Buy MOTS-c Peptides EU

MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial 12S rRNA open reading frame. This bioactive peptide has emerged as a significant regulator of cellular metabolism, oxidative stress responses, and metabolic homeostasis in research applications. Unlike traditional peptides encoded by nuclear DNA, MOTS-c originates from the mitochondrial genome, making it a unique tool for investigating mitochondria-nucleus communication pathways. Buy MOTS-c research peptide EU

First characterized in 2015, MOTS-c has demonstrated research potential in metabolic studies, including glucose metabolism, insulin sensitivity, and energy expenditure investigations. For researchers conducting advanced metabolic and mitochondrial studies, this peptide offers a novel approach to understanding cellular energy regulation. Buy MOTS-c research peptide EU

All products are strictly for research use only and comply with EU laboratory standards. Visit our homepage at euresearchpeptides.com to explore our full range of buy peptides EU products.

Purity Specifications & Analytical Data

Every batch of MOTS-c undergoes rigorous quality control testing to ensure research-grade standards for high purity peptides Germany and laboratory peptides Netherlands applications.

HPLC Analysis

• Method: Reverse-phase HPLC with C18 column

• Purity threshold: >99% area normalization

• Retention time consistency: ±2% across batches

Mass Spectrometry

• Method: ESI-TOF MS

• Expected m/z: Multiple charged species observed

• Verification: Molecular weight confirmation within ±0.05%

Certificate of Analysis Parameters

• Peptide content: Determined by amino acid analysis

• Water content: <5% by Karl Fischer

• Acetate/Trifluoroacetate content: <10%

• Microbial limits: Sterile, no bacterial growth

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Solubility Profile

Proper solubilization is essential for research applications of this peptide synthesis Europe product.

Solubilization Protocol

1. Allow lyophilized peptide to reach room temperature before opening

2. Add sterile water or buffer directly to vial

3. Gently swirl to dissolve – do not vortex or shake vigorously

4. Allow 2-3 minutes for complete dissolution

5. Dilute further with desired buffer or saline

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Stability Data & Storage Recommendations

Critical Stability Notes

• Prevent freeze-thaw cycles of reconstituted solutions

• Store lyophilized peptide desiccated to prevent moisture absorption

• For long term storage of reconstituted MOTS-c, add 0.1% HSA or BSA as carrier protein

• Protect from light exposure during handling

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Known Research Applications

Metabolic Regulation Studies

MOTS-c activates the AMPK pathway, a key energy sensor in cellular metabolism. Research has demonstrated that MOTS-c increases glucose clearance and enhances skeletal muscle AMPK activation . Studies show it increases GLUT4 expression and may prevent high-fat diet induced metabolic changes in research models.

Cellular Metabolism & Energy Homeostasis

In cellular studies, MOTS-c increases glycolysis in an AMPK-dependent manner. It decreases 5-methyl-tetrahydrofolate levels, blocking de novo purine biosynthesis while increasing AICAR accumulation. These mechanisms position MOTS-c as a valuable tool for metabolic research applications.

Osteogenic Differentiation Research

At concentrations of 1 µM, MOTS-c has been shown to increase osteogenic differentiation and the formation of calcified nodules in rat bone mesenchymal stem cells.

Oxidative Stress & Cellular Protection

Research has identified MOTS-c as a key regulator of oxidative stress responses. Studies demonstrate that MOTS-c significantly attenuates oxidative damage through activation of the AMPK/SIRT1 pathway, reducing apoptosis markers and senescence in cell models.

Intervertebral Disc Degeneration Research

MOTS-c has been investigated for its therapeutic potential in intervertebral disc degeneration studies. Research shows it can reduce reactive oxygen species production and preserve disc height in research models.

Age-Related Macular Degeneration Research

Recent studies have explored MOTS-c in retinal cell survival research. Lower doses (500 nM) demonstrated more significant impacts on apoptosis, inflammation, and mitochondrial biogenesis in differentiated retinal pigment epithelial cells compared to higher concentrations.

Cardiovascular Research

In rat models of secondary myocardial remodeling, MOTS-c administration increased AMPK activation and reduced protein levels of angiotensin II type 1 and endothelin B receptors.

Avian Metabolic Research

Avian MOTS-c sequences have been characterized and shown to modulate the AKT signaling pathway, with highest expression levels observed in cardiac tissue. Fasting significantly reduces MOTS-c expression, suggesting metabolic regulatory functions .

Key Research Citations Available Upon Request:

• AMPK/SIRT1 pathway activation studies

• Metabolic homeostasis investigations

• Stem cell differentiation research

• Oxidative stress protection protocols

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Reconstitution Guidelines

For researchers sourcing BPC-157 Europe or GLP-1 research peptides EU alongside MOTS-c, follow these established reconstitution protocols:

Standard Reconstitution Protocol

1. Preparation – Allow lyophilized MOTS-c vial to reach room temperature (20-30 minutes)

2. Sterilization – Wipe rubber stopper with 70% alcohol prep pad

3. Calculate Volume – Determine required diluent volume based on desired concentration

4. Reconstitute – Add sterile water for injection or 0.9% saline to vial

5. Gentle Mixing – Swirl or invert gently until complete dissolution

6. Inspect – Solution should be clear with no particulates

Concentration Guidelines

Storage After Reconstitution

• Refrigerate at 2-8°C for same-week use (2-7 days maximum)

• For longer storage, aliquot and freeze at -20°C

• Add carrier protein (0.1% BSA) for enhanced stability during frozen storage

• Label with concentration, date, and researcher initials

• Discard if solution becomes cloudy or particulate forms

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Proper Handling Protocols

Required Safety Equipment

• Powder-free nitrile gloves

• Safety goggles or face shield

• Laboratory coat

• Biosafety cabinet for reconstitution

• Sharps container for needle disposal

Handling Precautions

All research chemicals EU compliant products require strict adherence to safety protocols:

• Never pipette by mouth

• Avoid skin contact with peptide solutions

• Work in well-ventilated area or fume hood

• Decontaminate spills with 10% bleach solution

• Wash hands thoroughly after handling

Preparation Environment

Reconstitution should be performed in a clean laboratory environment with:

• Sterile work surface

• Unopened sterile syringes and needles

• Fresh alcohol prep pads for each vial

• Clean gloves changed between compounds

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Safety Considerations

Toxicity Profile

Based on available research data:

• Acute toxicity: Not established; handle as potentially hazardous

• Skin contact: May cause irritation

• Eye contact: May cause irritation

• Inhalation: Avoid breathing aerosolized powder

• Ingestion: Not for human consumption

Emergency Procedures

Decontamination

• Equipment: 70% ethanol or 10% bleach solution

• Spills: Absorb with inert material, disinfect area

• Waste disposal: Chemical waste per local regulations

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Mechanism of Action Research Summary

MOTS-c exerts its biological effects primarily through:

1. AMPK Pathway Activation – Enhances cellular energy sensing and glucose metabolism

2. SIRT1 Modulation – Influences oxidative stress responses and cellular aging pathways

3. Nuclear Gene Regulation – Translocates to nucleus to regulate gene expression

4. AKT Signaling – Modulates cell survival and metabolic pathways

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Why Choose Euresearchpeptides.com

As a premium EU-based online retailer specializing in peptide supplier Spain and buy peptides EU products:

• EU Warehousing – Fast shipping across Germany, France, Netherlands, Spain, and all EU member states

• Verified Purity – Every batch includes Certificate of Analysis with HPLC/MS data

• EU Compliance – Full adherence to EU research chemical regulations

• Discreet Packaging – Research purposes only, professional laboratory packaging

• Technical Support – Dedicated support for reconstitution and protocol questions

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SEO FAQ Section – High Commercial Intent

Q1: Where can I buy MOTS-c research peptide in Europe?

You can purchase MOTS-c research peptide directly from euresearchpeptides.com, a trusted buy peptides EU supplier with warehouse operations across Europe. We offer fast shipping to Germany, France, Netherlands, Spain, and all EU countries with verified high purity 99%+ HPLC tested product. Shop now

Q2: What is the molecular weight and sequence of MOTS-c?

MOTS-c has a molecular weight of 2174.60 g/mol with the molecular formula C101H152N28O22S2. The full amino acid sequence is MRWQEMGYIF YPRKLR (H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH). CAS number is 1627580-64-6. View specifications

Q3: What purity level is guaranteed for your MOTS-c?

Our MOTS-c is verified at >99% purity by HPLC analysis. Each batch undergoes rigorous quality control testing including mass spectrometry confirmation. You receive a comprehensive Certificate of Analysis with every order for complete research documentation. Order now

Q4: How should I store MOTS-c peptide?

Store lyophilized MOTS-c at -20°C protected from light. The powder remains stable for 36 months when stored properly. After reconstitution, store at 4°C for 2-7 days or aliquot and freeze at -20°C for longer storage. Adding 0.1% BSA as carrier protein is recommended for frozen storage. Storage guide

Q5: What is the recommended reconstitution protocol for MOTS-c?

Reconstitute MOTS-c in sterile water for injection or 0.9% saline at a minimum concentration of 100 µg/mL. Allow the lyophilized powder to reach room temperature before opening, add diluent gently, and swirl to dissolve. Do not vortex or shake vigorously as this may damage the peptide structure. View protocol

Q6: What research applications is MOTS-c used for?

MOTS-c is widely studied in metabolic research, glucose metabolism investigations, AMPK pathway activation studies, oxidative stress protection research, stem cell differentiation studies, cardiovascular research, and age-related disease models including age-related macular degeneration studies. Learn more

Q7: Does MOTS-c activate the AMPK pathway?

Yes, research has demonstrated that MOTS-c activates the AMPK pathway, a key cellular energy sensor. Studies show MOTS-c increases AMPK activation, enhances glucose clearance, and increases GLUT4 expression in research models. This mechanism is central to its metabolic research applications. Buy now

Q8: Do you ship MOTS-c to my country in Europe?

We ship to all EU member countries including Germany, France, Netherlands, Spain, Italy, Belgium, Austria, Switzerland, Sweden, Denmark, Poland, and more as a leading research chemicals EU compliant distributor. Orders typically arrive within 3-7 business days. Check shipping

Q9: What is the CAS number for MOTS-c?

The CAS registry number for MOTS-c is 1627580-64-6. This unique identifier is used for chemical databases and regulatory documentation. Technical data sheet

Q10: Is MOTS-c soluble in water?

Yes, MOTS-c is soluble in sterile water at concentrations of 100 µg/mL or higher. For specialized applications requiring higher concentrations, DMSO can be used (4 mg/mL). For in vivo studies, 0.9% saline or CMC-Na suspension (5 mg/mL) are suitable options. Order today

Q11: Can MOTS-c be used for nasal spray research studies?

Yes, MOTS-c can be formulated for nasal spray research applications when proper solubility and stability protocols are followed. We recommend pairing with our Research Spray Add-on Kit for complete administration supplies. Shop kit

Q12: What is the difference between wild-type MOTS-c and K14Q mutant?

The K14Q mutant of MOTS-c contains a lysine to glutamine substitution at position 14. This genetic variant (m.1382A>C) has been associated with exceptional longevity research studies and may be of particular interest for aging research applications. Contact us