Description

Buy HGH Fragment 176-191 – Research Peptide Online

HGH Fragment 176-191, also known as human growth hormone fragment 176-191, is a synthetic peptide corresponding to the C-terminal region of the human growth hormone molecule. This research compound has gained significant attention in scientific literature for its distinct mechanism of action that appears to separate metabolic effects from growth-promoting activities. Unlike full-length growth hormone, this fragment targets lipid metabolism pathways without affecting blood glucose or insulin sensitivity in research models. Buy HGH Fragment 176-191 Peptides EU

For researchers conducting advanced metabolic studies, this peptide offers a targeted approach to investigating lipolysis and lipogenesis inhibition. The compound is structurally related to AOD-9604, with which it shares significant sequence homology. Buy HGH Fragment 176-191 Peptides EU

All products are strictly for laboratory research use only and comply with EU standards. Explore our complete range of research compounds at euresearchpeptides.com.

Sequence Information

Amino Acid Sequence (Three-Letter Code):
H-Phe-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH

Amino Acid Sequence (One-Letter Code):
FLRIVQCRSVEGSCGF

Structural Features:
This peptide contains a disulfide bridge between the two cysteine residues at positions 7 and 14, forming a cyclic structure essential for its biological activity in research models.

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Purity Specifications & Analytical Data

Every batch of HGH Fragment 176-191 undergoes rigorous third-party testing to ensure research-grade quality.

All certificates of analysis are available upon request and include lot-specific HPLC chromatograms.

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Solubility Profile

HGH Fragment 176-191 can present solubility challenges due to its hydrophobic nature and disulfide bridge structure. Proper solvent selection is critical for successful reconstitution.

Recommended Reconstitution Protocol:

1. Prepare 5% acetic acid solution using sterile water

2. Add calculated volume to lyophilized peptide vial

3. Allow solution to flow gently down the inner glass wall

4. Swirl gently until complete dissolution is achieved

5. If needed, dilute further with sterile saline or bacteriostatic water

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Stability Data

Understanding stability parameters is essential for maintaining peptide integrity throughout research protocols.

Important Stability Notes:

• Lyophilized peptide is stable at room temperature for up to 3 weeks when desiccated

• Upon reconstitution, store at 4°C for 2-7 days for short-term use

• For long-term storage of reconstituted solutions, aliquot and freeze below -18°C

• Avoid repeated freeze-thaw cycles

• Protect from light and moisture

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Recommended Storage Conditions

Before Reconstitution:

• Store lyophilized powder desiccated below -18°C for long-term storage

• Allow vial to reach room temperature before opening to prevent condensation

• Keep in original packaging until use

After Reconstitution:

• Refrigerate at 2-8°C for up to 7 days if used regularly

• For longer storage, aliquot into sterile vials and freeze at -20°C

• Never refreeze thawed aliquots

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Known Research Applications

Metabolic and Lipid Research

HGH Fragment 176-191 has been extensively studied for its effects on lipid metabolism. Research indicates this peptide stimulates lipolysis (fat breakdown) while inhibiting lipogenesis (fat formation) without affecting growth or insulin resistance. These characteristics make it valuable for metabolic pathway investigations.

Oncology Research Applications

A 2022 study published in Drug Design, Development and Therapy demonstrated that HGH Fragment 176-191 enhances the toxicity of doxorubicin-loaded chitosan nanoparticles against MCF-7 breast cancer cells. Molecular docking simulations revealed that the peptide binds to breast cancer receptors and improves doxorubicin binding to these same targets. The dual-loaded nanoparticles showed greater anti-proliferative activity against breast cancer cell lines compared to doxorubicin alone.

Glucose Metabolism Studies

Early research published in the American Journal of Physiology examined the hyperglycemic action of synthetic C-terminal fragments of human growth hormone. The study found that peptides containing the amino acid sequence 178-191 significantly reduced insulin sensitivity in animal models, providing insights into glucose regulation mechanisms.

Adipose Tissue Research

The peptide has been investigated for applications in adipose tissue studies, including research on HIV-associated lipodystrophy and abdominal fat accumulation. Unlike full-length growth hormone, this fragment shows no impact on glycemic control in research models.

Citation Summary

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Proper Handling Protocols

Required Safety Equipment

• Nitrile gloves (powder-free)

• Safety goggles

• Laboratory coat

• Work in a laminar flow hood or clean environment

Handling Precautions for Research Use Only

• Never pipette by mouth

• Avoid skin contact with reconstituted solutions

• Use sterile techniques for all manipulations

• Decontaminate work surfaces before and after use

• Dispose of contaminated materials in appropriate biohazard waste

Reconstitution Guidelines for Research Peptides

Step-by-Step Protocol:

1. Preparation – Remove peptide vial from freezer and allow to reach room temperature (15-20 minutes)

2. Sterilization – Wipe rubber stopper with 70% alcohol prep pad

3. Solvent Preparation – Prepare 5% acetic acid solution or use DMSO as recommended

4. Air Equalization – Using a sterile 1mL syringe, inject air volume equal to desired solvent volume into the vial

5. Solvent Addition – Slowly add solvent down the inner glass wall, never directly onto lyophilized powder

6. Dissolution – Swirl gently until solution is clear. Do not shake vigorously

7. Dilution (Optional) – Dilute to working concentration using sterile saline or bacteriostatic water

8. Storage – Label vial with concentration, date, and researcher initials

Concentration Reference Table

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Safety Considerations

Hazard Identification

• For laboratory research use only

• Not for human or veterinary use

• May cause skin and eye irritation

• Potential respiratory irritant in powder form

First Aid Measures

Handling and Storage

• Store in original container in freezer below -18°C

• Keep container tightly closed

• Use only in well-ventilated areas

• Wash hands thoroughly after handling

Disposal Guidelines

• Decontaminate all materials with 10% bleach solution

• Dispose of in accordance with local laboratory waste regulations

• Use sharps containers for needles and syringes

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Why Choose Euresearchpeptides.com

As a premium EU-based online retailer specializing in research peptides, we deliver:

• EU Warehousing – Fast shipping across Germany, France, Netherlands, Spain, and all EU member states

• Verified Purity – Every batch includes Certificate of Analysis with HPLC-MS data

• EU Compliance – Full adherence to EU research chemical regulations

• Discreet Packaging – Professional laboratory packaging for research purposes

• Competitive Pricing – Best value for high-purity research compounds

Shop with confidence for all your buy peptides EU needs.

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SEO FAQ Section – High Commercial Intent

Q1: Where can I buy HGH Fragment 176-191 research peptide in Europe?

You can purchase HGH Fragment 176-191 directly from euresearchpeptides.com, a trusted supplier for buy peptides EU with warehouse operations across Europe. We offer fast shipping to Germany, France, Netherlands, Spain, and all EU countries. Shop now

Q2: What is the purity of your HGH Fragment 176-191?

Our HGH Fragment 176-191 exceeds 99% purity as verified by HPLC-MS and CHNS analysis. Each batch includes a Certificate of Analysis from third-party testing. View specifications

Q3: What is the molecular weight of HGH Fragment 176-191?

The molecular weight of HGH Fragment 176-191 is 1799.08 g/mol with molecular formula C78H125N23O22S2. Technical data

Q4: How do I reconstitute HGH Fragment 176-191 for research?

Due to potential solubility issues with water alone, we recommend reconstituting with 5% acetic acid or DMSO for complete dissolution. Detailed reconstitution protocols are provided with each order. View protocol

Q5: What is the difference between HGH Fragment 176-191 and AOD-9604?

HGH Fragment 176-191 and AOD-9604 are closely related peptides. AOD-9604 has the sequence H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH (starting with tyrosine), while HGH Fragment 176-191 starts with phenylalanine. Both are used in metabolic research. Compare products

Q6: How should I store HGH Fragment 176-191?

Store lyophilized peptide desiccated below -18°C for long-term storage. Upon reconstitution, store at 4°C for up to 7 days or freeze in aliquots at -20°C for longer storage. Storage guide

Q7: Is HGH Fragment 176-191 stable at room temperature?

Lyophilized HGH Fragment 176-191 is stable at room temperature for approximately 2 months but should be stored below -18°C for long-term preservation. Stability data

Q8: Do you ship to my country in Europe?

We ship to all EU member countries including Germany, France, Netherlands, Spain, Italy, Belgium, Austria, Switzerland, Sweden, and Denmark as a leading research chemicals EU compliant distributor. Check shipping

Q9: What research applications is HGH Fragment 176-191 used for?

Research applications include metabolic studies, lipid metabolism investigation, lipolysis and lipogenesis research, oncology research (breast cancer studies), and glucose metabolism studies. Research applications

Q10: Can I receive a Certificate of Analysis with my order?

Yes, every order includes a Certificate of Analysis with HPLC-MS purity data and lot-specific testing results. Contact our team for batch-specific COA requests. Contact us