Description

Buy MK677 – 60x 12.5mg | High Purity Ibutamoren Mesylate for Research

Welcome to euresearchpeptides.com — your premier EU-based supplier of research peptides, SARMs, and biochemicals. Our MK677 (Ibutamoren Mesylate) is manufactured to the highest purity specifications, designed exclusively for laboratory research applications. Researchers across Europe, including Germany, France, the Netherlands, Spain, and the UK, trust us for compliant, high-purity research compounds. buy mk677 60x 12.5mg peptides EU

What Is MK677 (Ibutamoren Mesylate)?

MK677, also known as Ibutamoren Mesylate or MK-0677, is a potent, orally-active , non-peptide growth hormone secretagogue receptor (GHSR) agonist. Unlike peptide-based growth hormone-releasing hormones that require injection, MK677 is a small molecule that mimics the action of ghrelin, binding to the ghrelin receptor in the pituitary gland to stimulate natural pulsatile growth hormone (GH) release. buy mk677 60x 12.5mg peptides EU

Catalog Details: CAS 159752-10-0 | Molecular Formula C28H40N4O8S2 | Molecular Weight 624.77 g/mol

This product is supplied as 60 individually measured 12.5mg units of lyophilized powder, providing researchers with precise, pre-measured aliquots for reproducible experimental protocols. Purity is verified at >98% by HPLC-MS, with full Certificates of Analysis available for each batch.

How MK677 Works: Mechanism of Action in Research

MK677 functions as a selective agonist of the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, with an EC50 of 1.3 nM in rat pituitary cell assays . Upon receptor binding, MK677 triggers downstream signaling cascades that stimulate the anterior pituitary to release growth hormone in episodic pulses.

Key research applications include:

• Endocrinology Studies: Investigating GH-IGF-1 axis modulation and feedback mechanisms

• Metabolic Research: Examining effects on lean body mass composition and protein synthesis

• Neuroendocrinology: Studying ghrelin receptor pharmacology in appetite and sleep regulation

• Aging Research: Exploring GH secretagogues in age-related decline models

In preclinical studies, MK677 demonstrated a 20.4-fold increase in peak GH concentrations at 0.25 mg/kg in beagle models, with sustained activation of the GH-IGF-1 axis . Unlike exogenous GH administration, MK677 preserves the natural pulsatile pattern of GH secretion, which is critical for normal physiological feedback loops .

Performance Benefits for Research Applications

Safety Considerations and Proper Handling Protocols

Important Notice: This product is supplied for in vitro laboratory research use only. Not for human consumption, veterinary use, or diagnostic applications.

Handling Requirements:

• Use appropriate personal protective equipment (PPE): gloves, lab coat, eye protection

• Work in a certified chemical fume hood when handling powder form

• Avoid inhalation, skin contact, and ingestion

• Dispose of materials in accordance with local hazardous waste regulations

Storage Recommendations:

• Store lyophilized powder at -20°C for up to 36 months

• At 4°C, powder remains stable for up to 6 months

• Once reconstituted in solvent, store at -80°C for 6 months or -20°C for 1 month

• Avoid repeated freeze-thaw cycles; aliquot upon first reconstitution

Reconstitution Guidelines

For accurate research outcomes, proper reconstitution is essential. Based on solubility profiles :

Recommended Protocol:

1. Allow the vial to reach room temperature before opening to prevent condensation

2. Add the calculated volume of solvent to achieve desired concentration

3. Gently swirl (do not vortex vigorously) until complete dissolution

4. Aliquot into single-use portions to prevent freeze-thaw degradation

5. Store aliquots according to stability data above

Quality and Manufacturing Standards

At euresearchpeptides.com, we maintain rigorous quality control exceeding typical industry standards. Each batch undergoes:

• HPLC-MS Purity Analysis: >98% minimum, with full chromatogram documentation

• Heavy Metal Testing: Compliance with ICH Q3D guidelines (As, Pb, Cd, Hg <10 ppm)

• Residual Solvent Analysis: Headspace GC testing per ICH Q3C

• Identity Confirmation: FTIR and NMR spectroscopy

• Certificate of Analysis: Provided with every shipment, including batch-specific data

Why Researchers Choose euresearchpeptides.com:

• EU-based facility ensuring fast, compliant shipping across Europe

• ISO 9001:2015 certified manufacturing partner

• Transparent documentation with full analytical data

• Dedicated customer support for protocol inquiries

• Secure payment processing and discreet packaging

Who This Product Is Best Suited For

Compliance and Legal Information

euresearchpeptides.com operates in full compliance with EU regulations for research chemicals. Our products are:

• Shipped with appropriate safety data sheets (SDS)

• Classified for research use only under REACH regulations

• Exported with proper customs documentation (where applicable)

• Not scheduled under controlled substance legislation in most EU member states

Customers are responsible for ensuring compliance with local regulations regarding import and use of research compounds.

👉 Explore our complete catalog of research peptides, including GLP-1 agonists, BPC-157, and other SARMs, at our official homepage.

 

Frequently Asked Questions (FAQ) – High Commercial Intent

1. Can I buy MK677 for research in Europe?

Yes. euresearchpeptides.com supplies MK677 (Ibutamoren Mesylate) exclusively for laboratory research use to qualified researchers across the EU, including Germany, France, Netherlands, Spain, Italy, and the UK. Order online for fast, compliant shipping.

2. What is the difference between MK677 and Ibutamoren Mesylate?

MK677 and Ibutamoren Mesylate refer to the same compound. MK677 is the developmental code name assigned by Merck during preclinical research. Ibutamoren Mesylate is the chemical name for the methanesulfonate salt form. Both share CAS number 159752-10-0 .

3. What purity is your MK677?

Our MK677 is tested at >98% purity by HPLC-MS, with full Certificates of Analysis available for each batch. Third-party verification is available upon request .

4. How should I store MK677 powder?

Store lyophilized MK677 powder at -20°C in a sealed, desiccated container away from light. Under these conditions, the compound remains stable for up to 36 months. At 4°C, stability is 6 months .

5. Is MK677 soluble in water?

Yes. MK677 mesylate is soluble in water at concentrations up to 92 mg/mL (147.25 mM). It also dissolves readily in DMSO and ethanol at equivalent concentrations .

6. Do you ship MK677 to the UK?

Yes. We ship research peptides, including MK677, to the United Kingdom with appropriate customs documentation. Customers are responsible for verifying local import regulations before ordering.

7. What is the mechanism of action of MK677?

MK677 is a potent, selective, orally-active agonist of the ghrelin receptor (GHSR), with an EC50 of 1.3 nM. It stimulates endogenous pulsatile growth hormone release from the pituitary gland, mimicking the action of the hormone ghrelin .

8. Can I get a bulk discount on MK677?

Yes. For bulk orders of MK677 or other research peptides, please contact our sales team at sales@euresearchpeptides.com for volume pricing and custom quotations.

9. What is the half-life of MK677 in research models?

MK677 has an approximate half-life of 24 hours, supporting once-daily dosing in preclinical research protocols. Pharmacokinetic studies demonstrate sustained elevation of GH and IGF-1 levels with daily administration .

10. Is MK677 legal to buy in Germany?

MK677 is not a controlled substance under the German Betäubungsmittelgesetz (BtMG) and may be purchased for legitimate laboratory research purposes. All customers must comply with local regulations and provide appropriate institutional justification when required.