Description

Buy Thoroughbred Labs 5-Amino-1MQ Peptides EU

Welcome to euresearchpeptides.com — your trusted EU-based supplier of premium research peptides, including high-purity 5-Amino-1MQ. As a leading peptide supplier Europe, we provide research-grade compounds to laboratories, research institutions, and scientific professionals across the European Union, United Kingdom, Switzerland, and worldwide. Buy 5-Amino-1MQ peptides EU

What Is 5-Amino-1MQ?

5-Amino-1MQ (also known as NNMTi or 5-amino-1-methylquinolinium iodide) is a potent, selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). With CAS number 42464-96-0 and molecular formula C₁₀H₁₁N₂⁺, this research compound has emerged as a valuable tool for metabolic, obesity, and aging research. Buy 5-Amino-1MQ peptides EU

Unlike broad-spectrum metabolic compounds, 5-Amino-1MQ specifically targets NNMT, an enzyme overexpressed in adipose tissue, liver, and certain cancers. By inhibiting NNMT, this research peptide helps scientists investigate NAD+ salvage pathway regulation, cellular energy metabolism, and epigenetic modifications.

Mechanism of Action

NNMT catalyzes the methylation of nicotinamide (NAM) using S-adenosyl methionine (SAM), producing 1-methylnicotinamide (1-MNA). This process creates a “methylation sink” that depletes SAM and reduces NAD+ bioavailability. 5-Amino-1MQ binds selectively to the NNMT substrate binding site with an IC50 of 1.2 μM, effectively blocking this enzymatic activity.

The downstream effects of NNMT inhibition include:

• Increased intracellular NAD+ levels

• Enhanced SIRT1 and SIRT3 activity

• Restored SAM/SAH ratio for proper methylation capacity

• Improved mitochondrial oxidative metabolism

Research Applications

Metabolic and Obesity Research

Preclinical studies demonstrate that 5-Amino-1MQ reduces body weight and visceral adiposity in diet-induced obese (DIO) mouse models without affecting food intake. Treatment increases energy expenditure, shrinks adipocyte size, and reduces adipose tissue inflammation. For researchers investigating metabolic dysfunction, this compound offers a mechanism distinct from appetite suppressants.

Insulin Sensitivity and Glycemic Control

Studies show improved insulin tolerance and fasting glucose following 5-Amino-1MQ administration, with normalized insulin signalling (Akt phosphorylation) in adipose and liver tissues. This makes the compound valuable for type 2 diabetes and metabolic syndrome research.

NAD+ Restoration and Anti-Aging Research

NNMT expression progressively increases in aging skeletal muscle, contributing to sarcopenia. 5-Amino-1MQ treatment enhances muscle stem cell proliferation, fusion, and regenerative capacity in aged mice. Researchers studying geroscience and NAD+ biology utilize this compound to investigate age-related metabolic decline.

Hepatic Steatosis and Lipid Metabolism

Animal models demonstrate that NNMT inhibition reduces hepatic lipogenesis (SREBP1c/FASN), lowers plasma triglycerides and cholesterol, and decreases liver fat accumulation. These findings support research into non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia.

Oncology Research

NNMT overexpression correlates with poor prognosis and global hypomethylation in several cancers. 5-Amino-1MQ reduces migratory and epithelial-mesenchymal transition (EMT) phenotypes in vitro, serving as a tool compound for cancer metabolism studies.

Handling and Storage Guidelines

Proper handling ensures compound integrity and experimental reproducibility.

Storage: Store lyophilized powder at -20°C, protected from light. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Reconstitution: For research use, dissolve in DMSO or sterile water as appropriate for your experimental protocol.

Stability: Reconstituted solutions should be stored at 4°C and used within a few days, or aliquoted and frozen for extended storage.

Safety Considerations

5-Amino-1MQ is for laboratory research use only. Not for human or veterinary consumption.

Hazard Classification: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation).

Precautionary Measures:

• Use only in well-ventilated areas or under fume hood

• Wear appropriate PPE (gloves, lab coat, eye protection)

• Wash thoroughly after handling

• Store locked up, out of reach of unauthorized personnel

Why Choose euresearchpeptides.com?

As a premier research peptides Europe supplier, we differentiate ourselves through:

Quality Assurance: Every batch undergoes third-party HPLC/MS purity testing with publicly available certificates of analysis.

European Operations: Based in the EU, we offer fast, reliable shipping to Germany, France, Netherlands, Spain, Italy, UK, and throughout Europe without customs delays.

Research-Grade Standards: Our products meet rigorous specifications for laboratory use, free from adulterants and flow agents.

Competitive Pricing: Volume discounts available for institutional and bulk orders.

Expert Support: Our team understands research protocols and can assist with product selection.

👉 Explore our complete catalog of research peptides at our official homepage.

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Frequently Asked Questions

What is 5-Amino-1MQ used for in research?

5-Amino-1MQ is primarily used as a nicotinamide N-methyltransferase (NNMT) inhibitor in metabolic, obesity, aging, and cancer research. It helps scientists investigate NAD+ metabolism, energy expenditure, adipocyte function, and epigenetic regulation.

What purity level does your 5-Amino-1MQ have?

Our Thoroughbred Labs 5-Amino-1MQ is tested at ≥98% purity by HPLC, with third-party verification for quality assurance.

How should I store 5-Amino-1MQ?

Store lyophilized powder at -20°C in a sealed container, protected from light and moisture. Reconstituted solutions should be used promptly or aliquoted and frozen.

Is 5-Amino-1MQ approved for human use?

No. 5-Amino-1MQ is strictly for laboratory research purposes only and is not approved for human or veterinary consumption by the EMA, FDA, or any regulatory agency.

Do you ship to my country?

We ship to all EU member states, United Kingdom, Switzerland, Norway, and select international destinations. Contact us for specific shipping inquiries.

Can I get a Certificate of Analysis?

Yes. Each batch includes a COA with HPLC purity data. Contact our team for batch-specific documentation.

What is the mechanism of NNMT inhibition?

5-Amino-1MQ selectively binds to the NNMT substrate binding site with an IC50 of 1.2 μM, blocking nicotinamide methylation and preserving SAM for proper cellular methylation capacity.

Are there volume discounts available?

Yes. We offer tiered pricing for bulk orders. Contact our sales team for institutional pricing and large-quantity quotes.