DSIP

€43.00

PRODUCT OVERVIEW

Attribute	Specification
Brand	EU Research Peptides (euresearchpeptides.com)
Peptide Name	DSIP (Delta Sleep-Inducing Peptide, Emideltide)
Sequence	H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
Molecular Formula	C35H48N10O15
Molecular Weight	848.81 g/mol
CAS Number	62568-57-4 (free base)
Purity	>98% (HPLC)
Salt Form	Acetate / TFA (specify preference)
Endotoxin Level	<0.05 EU/mg
Appearance	White to off-white lyophilized powder
Solubility	Soluble in sterile water (>0.5 mg/mL), bacteriostatic water, DMSO (10 mM)
Storage (Lyophilized)	-20°C or below, desiccated, protect from light
Storage (Reconstituted)	2-8°C for 2-7 days; -20°C for long-term with carrier protein
Stability at Room Temperature	3 weeks (lyophilized)
Half-life	~15 minutes in vitro
Shelf Life	12-24 months (lyophilized)
Country of Origin	EU (manufactured in ISO-certified facilities)
Shipping	Ice chest + ice pads, temperature-controlled packaging
Safety & Handling	For research use only. Not for human consumption. Use appropriate PPE.

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Description
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Description

Buy DSIP Peptide | Delta Sleep-Inducing Peptide for Research | High Purity Europe

Welcome to euresearchpeptides.com — your trusted source for premium, laboratory-grade research peptides in Europe. Our DSIP peptide (Delta Sleep-Inducing Peptide) is a synthetic neuropeptide extensively studied for its effects on sleep regulation, stress adaptation, and neuroprotection in research settings. buy DSIP peptide online Europe

What Is DSIP Peptide?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in 1977 from the cerebral venous blood of rabbits during thalamic stimulation. The peptide consists of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. DSIP is recognized for its ability to promote sleep by modulating delta wave activity in electroencephalogram (EEG) recordings across multiple mammalian species including rabbits, rats, mice, and humans. buy DSIP peptide online Europe

This peptide is strictly intended for laboratory research use only and is not for human consumption. Our DSIP is manufactured using solid-phase peptide synthesis (SPPS) and purified via high-performance liquid chromatography (HPLC) to achieve purity exceeding 98%. buy DSIP peptide online Europe

How DSIP Works: Mechanism of Action

In research models, DSIP exerts its biological effects through several well-characterized mechanisms:

Sleep Modulation: DSIP induces and promotes delta sleep (slow-wave sleep) in a dose-dependent manner. Research demonstrates a U-shaped activity curve for both dosage and infusion timing. Unlike traditional hypnotic compounds, DSIP appears to normalize sleep patterns rather than act as a sedative.

Stress Protection: DSIP demonstrates significant stress-protective and antioxidant effects, protecting brain mitochondria from hypoxia-induced damage. This neuroprotective property makes DSIP valuable for studying cellular stress responses.

Neurotransmitter Regulation: The peptide affects electrophysiological activity and neurotransmitter levels in the brain, including interactions with the serotonergic and dopaminergic systems.

Circadian Rhythm Influence: DSIP has been observed to affect circadian and locomotor patterns, hormonal levels, and psychological performance in research models.

Research Applications

Research Area	Application
Sleep Research	Delta wave modulation, insomnia models, circadian rhythm studies
Neuroprotection	Hypoxia protection, oxidative stress reduction, mitochondrial preservation
Stress Research	Stress adaptation, anxiety models, neuroendocrine response studies
Chronobiology	Circadian rhythm regulation, locomotor activity patterns
Neuropharmacology	Drug withdrawal studies, neurotransmitter interaction research
Immunohistochemistry	DSIP antibody development, tissue localization studies

Performance Benefits for Research

Attribute	Specification
Purity	>98% (HPLC verified)
Molecular Formula	C35H48N10O15 (free base)
Molecular Weight	848.81 g/mol (free base)
CAS Number	62568-57-4 (free base)
Sequence	H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
Appearance	White to off-white lyophilized powder
Alternative Names	Delta Sleep-Inducing Peptide, Emideltide
Endotoxin Level	<0.05 EU/mg
Salt Form	Acetate or TFA (specify upon order)

Solubility Profile

For optimal research results, follow these reconstitution guidelines:

Primary solvent: Sterile 18 MΩ-cm distilled water or bacteriostatic water
Minimum concentration: Reconstitute to not less than 100 µg/mL
Alternative solvents: Dilute acetic acid for enhanced solubility
Solubility in water: 0.5 mg/mL
Solubility in DMSO: 10 mM

Reconstitution Protocol:

Allow vial to reach room temperature (25-45 minutes) before opening
Briefly vortex or tap the vial to concentrate material at the bottom
Add sterile aqueous solution slowly down the vial wall
Invert the tube 5 times by hand for homogeneous solution – do not shake

Stability and Storage Recommendations

Condition	Storage Method
Lyophilized Powder	Store at -20°C or below, desiccated, protected from light
Room Temperature Stability	Stable for up to 3 weeks
Reconstituted Solution (Short-term)	Store at 2-8°C (35.6-46.4°F) for 2-7 days
Reconstituted Solution (Long-term)	Store at -20°C or below; add carrier protein (0.1% HSA or BSA)
Half-life in vitro	Approximately 15 minutes due to aminopeptidase degradation
Shelf Life	12-24 months when stored properly in lyophilized form

Important: Avoid repeated freeze-thaw cycles. Aliquot reconstituted peptide before freezing.

Handling Protocols

For research use only. Proper handling ensures experimental integrity:

Wear appropriate personal protective equipment (PPE) including gloves and lab coat
Allow lyophilized peptide to reach room temperature before opening to prevent condensation
Reconstitute just before use for best results and reproducibility
Do not vortex after reconstitution – gentle inversion only
Label aliquots with date, concentration, and lot number
Use sterile techniques throughout all handling procedures

Quality Standards at EU Research Peptides

Our DSIP peptide is manufactured under strict quality control protocols:

Synthesis: Solid-phase peptide synthesis (SPPS) with Fmoc chemistry
Purification: HPLC purification to >98% purity
Verification: Mass spectrometry (MS) confirmation of molecular weight
Quality Control: Each batch includes Certificate of Analysis (COA) with HPLC chromatogram and MS spectrum
Facility: ISO-classified cleanroom manufacturing
Shipping: Ice chest with ice pads for temperature-controlled delivery

Why Researchers Choose EU Research Peptides

European-Based Operations: We are strategically located in the EU, ensuring fast, reliable shipping across Europe without customs delays.

Premium Quality: Every peptide batch undergoes rigorous third-party testing for purity, stability, and endotoxin levels.

Research Compliance: All products are labeled “For Research Use Only” and comply with EU chemical regulations including REACH and CLP.

Technical Support: Our team provides comprehensive documentation including COAs, MSDS, and reconstitution protocols.

Competitive Pricing: Bulk discounts available for research institutions and volume orders.

👉 Explore our complete catalog of research peptides at our official homepage.

Safety Considerations

DSIP peptide is intended for laboratory research purposes only. It is not for human consumption, therapeutic use, or veterinary applications. The FDA has not approved DSIP for any therapeutic application. Researchers should:

Follow institutional biosafety guidelines
Use appropriate personal protective equipment (PPE)
Handle all peptides with sterile technique
Dispose of materials according to local regulations

Known Research Applications (Citations)

DSIP has been studied across multiple research domains:

Sleep Research: Schneider-Helmert D, Schoenenberger GA. “The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep.” Experientia. 1981;37(9):913-7
Radioimmunoassay Development: Ekman R, Larsson I, Malmquist M, Thorell JL. Radioimmunoassay of delta sleep-inducing peptide using an iodinated p-hydroxyphenylpropionic acid derivative as tracer
Immunohistochemistry: Charnay Y, Golaz J, Vallet PG, Bouras C. Production and immunohistochemical application of monoclonal antibodies against delta sleep-inducing peptide. J Chem Neuroanat. 1992
Neuroprotection: DSIP protects brain mitochondria from hypoxia-induced damage and exerts antioxidant effects

Frequently Asked Questions (FAQ)

What is DSIP peptide?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood in 1977 . It consists of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and is studied for its effects on sleep regulation, stress adaptation, and neuroprotection.

What is the molecular formula and weight of DSIP?

The molecular formula is C35H48N10O15 with a molecular weight of 848.81 g/mol (free base).

What is the CAS number for DSIP?

The CAS number for DSIP free base is 62568-57-4.

What purity level does EU Research Peptides offer for DSIP?

Our DSIP peptide is tested at >98% purity by HPLC with mass spectrometry confirmation. Each batch includes a Certificate of Analysis (COA) with detailed purity data.

How should I store DSIP peptide?

Lyophilized DSIP should be stored at -20°C or below, desiccated, and protected from light . It remains stable at room temperature for up to 3 weeks. After reconstitution, refrigerate at 2-8°C for 2-7 days or freeze at -20°C for long-term storage.

Is DSIP peptide soluble in water?

Yes, DSIP is soluble in water at a concentration of 0.5 mg/mL. For reconstitution, use sterile 18 MΩ-cm distilled water or bacteriostatic water at a minimum concentration of 100 µg/mL.

What is the recommended reconstitution protocol?

Allow the vial to reach room temperature for 25-45 minutes, briefly vortex to concentrate material, add sterile aqueous solution slowly, then invert the tube 5 times by hand. Do not shake or vortex after reconstitution.

What is the in vitro half-life of DSIP?

DSIP has a half-life of approximately 15 minutes in vitro due to degradation by aminopeptidases.

What are the primary research applications for DSIP?

DSIP is studied in sleep research (delta wave modulation), neuroprotection (hypoxia protection, oxidative stress reduction), stress research, circadian rhythm studies, and neuropharmacology (drug withdrawal studies) .

What is the amino acid sequence of DSIP?

The full sequence is H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH.

Is DSIP FDA approved for therapeutic use?

No, the FDA has not approved DSIP for any therapeutic application. DSIP is a research peptide intended for laboratory use only.

Can I purchase DSIP peptide in bulk?

Yes, EU Research Peptides offers volume discounts for bulk orders. Contact our customer service team for customized quotes.

How should reconstituted DSIP be stored for long-term use?

For long-term storage, add a carrier protein such as 0.1% HSA or BSA, then store at -20°C or below. Aliquot to avoid repeated freeze-thaw cycles.

What documentation is provided with each order?

Each order includes a Certificate of Analysis (COA), material safety data sheet (MSDS), and reconstitution protocol.

How long does shipping take within Europe?

Standard shipping within the EU takes 3-5 business days. Temperature-controlled express shipping options are available for urgent research needs.

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