Description

Buy Density Labs GW-501516 Cardarine | High Purity PPARδ Agonist for Research

Welcome to euresearchpeptides.com — the premier EU-based supplier of high-purity research peptides and research chemicals. We are proud to present Density Labs GW-501516 Cardarine, a premium selective PPARδ agonist designed exclusively for laboratory research applications. As a trusted peptide supplier Europe, we deliver high purity peptides Germany, peptides for research France, laboratory peptides Netherlands, and research peptides Spain with uncompromising quality standards. buy gw-501516 cardarine europe

What Is GW-501516 Cardarine?

GW-501516, also known as Cardarine, Endurobol, or GSK-516, is a potent and highly selective synthetic agonist of the peroxisome proliferator-activated receptor delta (PPARδ) . This research compound belongs to the metabolic modulators class and is characterized by the molecular formula C21H18F3NO3S2 with a molecular weight of 453.50 g/mol. buy gw-501516 cardarine europe

Developed originally for investigating metabolic disorders, cardiovascular diseases, dyslipidemia, and insulin resistance, GW-501516 has become a subject of significant scientific interest for researchers studying:

• Lipid metabolism and fatty acid oxidation pathways

• Metabolic syndrome and obesity research models

• Exercise physiology and endurance mechanisms

• PPARδ receptor activation and downstream gene expression

Mechanism of Action: PPARδ Agonism

GW-501516 functions by selectively binding to and activating the PPARδ receptor, with an EC50 of approximately 1 nM . This activation triggers a cascade of transcriptional changes that regulate genes involved in:

Fatty Acid Metabolism: The compound increases fatty acid β-oxidation in skeletal muscle cells, effectively switching fuel preference from glucose to lipids . This mechanism has been documented in isolated rat skeletal muscle studies where GW-501516 treatment altered metabolic substrate utilization .

Energy Homeostasis: By activating PPARδ, GW-501516 increases energy expenditure and reduces body fat accumulation. Research has shown its ability to induce genes involved in lipid catabolism and energy uncoupling .

Reverse Cholesterol Transport: In macrophages, fibroblasts, and intestinal cells, GW-501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 (ABCA1), inducing apolipoprotein A1-specific cholesterol efflux .

Technical Specifications

Solubility Profile

Proper solubility is essential for research applications. GW-501516 demonstrates the following solubility characteristics :

Stability Data and Storage Recommendations

Based on comprehensive stability analysis from multiple reference standards :

• Powder form (at -20°C): Stable for up to 3 years

• Powder form (at room temperature): Stable for up to 1 month

• In solvent (at -80°C): Stable for 1 year

• In solvent (at 4°C): Prepare fresh for optimal results

Storage Protocol:

1. Store lyophilized powder at -20°C upon receipt

2. Protect from light and moisture

3. Allow vial to reach room temperature before opening

4. After reconstitution, aliquot to avoid freeze-thaw cycles

5. Record date of first use on vial label

Known Research Applications

GW-501516 has been extensively studied in the following research contexts (citations available upon request):

Metabolic Research:

• Investigation of PPARδ-mediated fatty acid oxidation in skeletal muscle tissue

• Studies on insulin resistance reversal and glucose homeostasis

• Research into lipid metabolism disorders and dyslipidemia

Cardiovascular Research:

• Evaluation of HDL cholesterol elevation mechanisms

• Studies on atherosclerosis prevention

• Investigation of cardiac metabolic substrate utilization

Exercise Physiology:

• Research on endurance capacity and exercise mimetics

• Studies on muscle fiber type switching

• Investigation of AMPK and PPARδ signaling crosstalk

Inflammatory Research:

• PPARδ modulation of NF-κB activation

• Studies on anti-inflammatory properties in various tissue types

Quality Assurance: Why EU Research Peptides Trust Density Labs

Highest Purity Standards: Every batch of Density Labs GW-501516 undergoes rigorous analytical testing including HPLC (≥99% purity), NMR for structural confirmation, and LC-MS for mass verification .

EU-Compliant Manufacturing: Our products are manufactured in GMP-like facilities within the European Union, ensuring compliance with research chemicals EU compliant standards.

Third-Party Verified: We maintain batch-specific Certificates of Analysis accessible to researchers, providing full transparency on purity, identity, and residual solvent analysis.

Secure Supply Chain: As a dedicated buy peptides EU supplier, we maintain inventory within Europe, eliminating customs delays and ensuring rapid delivery to research facilities across Germany, France, Netherlands, Spain, and the United Kingdom.

Handling and Safety Protocols

For Laboratory Use Only: GW-501516 is classified as a research chemical and is not approved for human or veterinary therapeutic use. The World Anti-Doping Agency (WADA) prohibits this compound in competitive sports .

Personal Protective Equipment (PPE) Required:

• Nitrile gloves

• Laboratory coat

• Safety goggles

• Work within a certified fume hood

Reconstitution Guidelines:

1. Calculate required volume based on desired concentration using provided molarity calculator

2. Allow vial to equilibrate to room temperature before opening

3. Add appropriate solvent (DMSO for stock solutions; specific vehicles for in vivo)

4. Vortex gently until complete dissolution

5. Store reconstituted solution in aliquots at -80°C

Who This Product Is For

Why Choose euresearchpeptides.com?

We are not just a research peptides Europe retailer; we are a strategic partner to the scientific community. Our commitment includes:

• Same-day shipping for orders placed before 12:00 CET

• Discreet, temperature-controlled packaging

• Dedicated technical support for protocol questions

• Bulk pricing for institutional research accounts

• EU-based customer service in English, German, French, and Spanish

👉 Explore our complete catalog of research peptides and chemicals at our official homepage.

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Frequently Asked Questions (FAQ)

1. What is the molecular formula and weight of GW-501516?

Molecular Formula: C21H18F3NO3S2
Molecular Weight: 453.50 g/mol
CAS Number: 317318-70-0

2. What is the purity of Density Labs GW-501516?

Our GW-501516 is verified at ≥99% purity by HPLC analysis, with identity confirmed by NMR and LC-MS . Each batch includes a Certificate of Analysis detailing purity, residual solvents, and analytical methods used.

3. How should GW-501516 be stored for optimal stability?

Store lyophilized powder at -20°C in a sealed container protected from light and moisture. Under these conditions, the compound remains stable for up to 36 months . Avoid repeated freeze-thaw cycles after reconstitution.

4. What solvents are recommended for reconstitution?

• Stock solutions: Use DMSO (91 mg/mL maximum solubility)

• In vivo studies: Formulate with 5% DMSO + 40% PEG300 + 5% Tween80 + 50% ddH2O, or 5% DMSO + 95% corn oil

• Water: GW-501516 is insoluble in aqueous solutions without co-solvents

5. What research applications has GW-501516 been used for?

GW-501516 has been cited in research on fatty acid oxidation in skeletal muscle, reverse cholesterol transport, PPARδ-mediated gene expression, insulin resistance prevention, and exercise endurance mechanisms .

6. Is GW-501516 approved for human use?

No. GW-501516 is strictly a research chemical. It is not approved by any regulatory agency for human or veterinary therapeutic use. WADA prohibits its use in competitive sports .

7. How long does shipping take within Europe?

As an EU-based supplier, we ship to Germany, France, Netherlands, Spain, United Kingdom, and all European Union member states with delivery typically within 3-5 business days. Express shipping options are available at checkout.

8. Do you provide Certificates of Analysis for each batch?

Yes. Every product page includes a batch-specific Certificate of Analysis accessible via QR code or direct download. Our quality documentation includes HPLC chromatograms, NMR spectra, and mass spectrometry data.

9. What safety precautions should be taken when handling?

Always handle GW-501516 in a certified fume hood wearing appropriate PPE (nitrile gloves, lab coat, safety goggles). Avoid inhalation, ingestion, or skin contact. Follow institutional chemical safety guidelines for disposal.

10. Can I purchase GW-501516 for in vivo research?

Yes, our GW-501516 is suitable for both in vitro and in vivo research applications. We provide solubility data and formulation recommendations to support your specific research model requirements.