Description

Buy Cardarine GW-501516 | High Purity Research Peptide EU

Welcome to euresearchpeptides.com, your premium EU-based supplier of research chemicals and laboratory peptides. We offer high purity Cardarine GW-501516 for scientific research applications across Europe, including Germany, France, Netherlands, Spain, and the UK. buy cardarine gw-501516 peptides EU

What is Cardarine GW-501516?

Cardarine, known by its research code GW-501516 (2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid), is a potent peroxisome proliferator-activated receptor delta (PPARδ) agonist . Developed during the 1990s for metabolic disorder research, this synthetic compound has demonstrated significant potential in cardiovascular and metabolic disease studies. buy cardarine gw-501516 peptides EU

For European research laboratories, universities, and pharmaceutical development teams, GW-501516 serves as a critical tool compound for PPARδ pathway investigation. Unlike other research sarms and peptides for research, Cardarine operates through nuclear receptor activation rather than androgen receptor binding, making it unique among research chemicals EU compliant.

How Cardarine Works in Research Applications

The mechanism of action for GW-501516 involves selective activation of PPARδ receptors, with an EC50 of approximately 1 nM and 1000-fold selectivity over hPPARα and hPPARγ subtypes . This high selectivity allows researchers to study:

• Lipid Metabolism: PPARδ activation upregulates genes involved in fatty acid oxidation and energy uncoupling in skeletal muscle cells

• Reverse Cholesterol Transport: GW501516 increases ABCA1 expression and induces apolipoprotein A1-specific cholesterol efflux

• Insulin Sensitivity: Research demonstrates prevention of fatty acid-induced NF-κB activation and insulin resistance in skeletal muscle models

• Anti-inflammatory Activity: Reduction of IFNγ-induced TNFα and inducible NO synthase expression

Performance Benefits for Research

Solubility Profile and Handling

Proper solubility is essential for reproducible research results. GW-501516 demonstrates the following solubility characteristics :

• DMSO: 91 mg/mL (200.66 mM) – optimal for stock solutions

• Ethanol: 22 mg/mL (48.51 mM) – suitable for specific protocols

• Water: Insoluble – do not use aqueous solutions without co-solvents

For in vivo research applications, validated formulation methods include:

1. 5% DMSO + 40% PEG300 + 5% Tween80 + 50% ddH2O (4.55 mg/mL clarity)

2. 5% DMSO + 95% Corn oil (1.5 mg/mL for oral administration)

3. CMC-Na suspension (5 mg/mL homogeneous suspension)

Stability and Storage Recommendations

To maintain compound integrity for reproducible research:

• Powder Storage: -20°C (stable for 3 years)

• Solution Storage: -80°C (stable for 1 year)

• Shipping Stability: Room temperature shipping validated; powder stable for 1 month without cooling

• Light Sensitivity: Store in amber vials away from direct light

Research Applications and Citations

GW-501516 has been extensively cited in peer-reviewed literature for:

• Metabolic Disorder Research: Dyslipidemia, insulin resistance, and obesity models

• Cardiovascular Studies: HDL cholesterol elevation and LDL reduction in primate models

• Fibrosis Research: TGF-β induced profibrotic response suppression in asthmatic bronchial fibroblasts

• Exercise Physiology: Synergistic endurance enhancement with physical activity

Recent publications citing Cardarine GW-501516 include Cellular and Molecular Life Sciences (2025), PLOS ONE (2025), and ACS Omega (2022) .

Safety Considerations and Handling Protocols

For laboratory research use only. Not for human or veterinary diagnostic or therapeutic use .

Required Safety Equipment:

• Chemical fume hood or biosafety cabinet

• Nitrile gloves and lab coat

• Safety goggles

Handling Guidelines:

1. Weigh using precision balance in ventilated area

2. Dissolve in DMSO first for cell culture applications

3. Dilute with appropriate buffer (PBS or cell culture media) maintaining DMSO below 0.1% for cellular assays

4. Decontaminate surfaces with 70% ethanol after handling

Who Is This Research Product Best Suited For?

• Academic Research Laboratories: Metabolic and cardiovascular research programs

• Pharmaceutical R&D Teams: PPARδ agonist drug development

• Contract Research Organizations: In vivo and in vitro screening services

• Biotechnology Companies: Metabolic disease therapeutic research

• Graduate Research Programs: Thesis and dissertation projects in lipid metabolism

Why Researchers Trust euresearchpeptides.com

As a premium EU-based retailer specializing in buy peptides EU, high purity peptides Germany, and research peptides Europe, we deliver:

• Certified Purity: HPLC and NMR validation on every batch

• EU Warehousing: Fast shipping within Germany, France, Netherlands, Spain, and across Europe

• Competitive Pricing: Bulk research quantities available

• Technical Support: Expert guidance on solubility and protocol development

• Compliance: EU research chemical regulations adherence

👉 Explore our complete research catalog at our official homepage.

Frequently Asked Questions (FAQ)

What is the molecular formula and weight of GW-501516?

The molecular formula of Cardarine GW-501516 is C21H18F3NO3S2 with a molecular weight of 453.50 g/mol .

What purity levels do you offer for Cardarine?

Our Cardarine GW-501516 is validated at ≥98% purity by HPLC, with specific batches achieving 99.71% purity confirmed by NMR structural analysis .

How do I dissolve GW-501516 for cell culture research?

First dissolve in DMSO at 91 mg/mL to create a stock solution. Then dilute with cell culture media or PBS maintaining final DMSO concentration below 0.1% to avoid cellular toxicity .

What is the stability of Cardarine powder?

GW-501516 powder is stable for 3 years when stored at -20°C. Room temperature storage for up to one month does not affect biological activity, validated by quality inspection .

Is GW-501516 soluble in water?

No, Cardarine is insoluble in water. Use DMSO or ethanol for initial dissolution, followed by appropriate buffer dilution .

What research applications is GW-501516 used for?

GW-501516 is widely cited in metabolic disorder research, cardiovascular studies, dyslipidemia, insulin resistance, obesity, and fibrosis research .

How should I store reconstituted GW-501516 solutions?

Store prepared solutions at -80°C for up to 1 year. Avoid repeated freeze-thaw cycles to maintain compound integrity .

What are the EC50 values for PPARδ activation?

GW-501516 activates PPARδ with an EC50 of approximately 1 nM, demonstrating 1000-fold selectivity over PPARα and PPARγ subtypes .

Can you ship Cardarine to my country?

We ship from our EU warehouse to Germany, France, Netherlands, Spain, Italy, Belgium, Austria, Switzerland, and other European research destinations.

Is this product for human use?

No. This product is strictly for laboratory research purposes only. Not for human consumption, therapeutic use, or veterinary applications .