Description
Buy PT-141 Research Peptide | High Purity Bremelanotide EU
Welcome to euresearchpeptides.com — your trusted premium EU-based supplier of high-purity research peptides, SARMs, and laboratory chemicals. We specialize in providing PT-141 (Bremelanotide) to research institutions, laboratories, and qualified researchers across Europe, Germany, France, the Netherlands, Spain, and the United Kingdom. buy pt-141 research peptide europe
What Is PT-141 (Bremelanotide)?
PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It functions as a non-selective agonist of melanocortin receptors, specifically targeting MC3R and MC4R subtypes expressed in the central nervous system. buy pt-141 research peptide europe
First synthesized as a metabolite of Melanotan II, PT-141 was developed to investigate neurological signaling pathways involved in motivational and reward processes. Unlike linear peptides that degrade rapidly in vivo, PT-141 features a cyclic lactam ring structure that confers conformational rigidity and enhanced resistance to enzymatic degradation.
The peptide’s molecular design includes strategic modifications:
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D-phenylalanine substitution at position 3 to resist aminopeptidase cleavage
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Acetylated N-terminus mimicking endogenous α-MSH acetylation patterns
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C-terminal amidation improving bioavailability and receptor binding
How PT-141 Works: Mechanism of Action
PT-141 exerts its effects through activation of melanocortin receptors in the hypothalamus. Quantitative receptor profiling reveals the following binding affinities:
| Receptor | Binding Affinity (Ki) | Primary Distribution | Research Role |
|---|---|---|---|
| MC1R | 0.17 nM | Melanocytes | Pigmentation studies |
| MC3R | 2.1 nM | Hypothalamus, gut | Energy homeostasis |
| MC4R | 0.24 nM | CNS nuclei | Neurological signaling |
| MC5R | 6.3 nM | Exocrine glands | Sebum production |
The primary research focus centers on MC4R activation, which triggers downstream neuromodulation including increased dopamine release in the nucleus accumbens and ventral tegmental areas. This mechanism distinguishes PT-141 from peripherally acting compounds, making it valuable for studies of central nervous system regulation of motivation and behavior.
Research Applications
PT-141 is widely utilized in preclinical research across multiple domains:
Neurological Signaling Studies
Investigators purchase PT-141 for research into melanocortin receptor pathways within the central nervous system. Studies examine how MC4R activation influences neurotransmitter release patterns and behavioral regulation .
Motivational and Reward System Research
The peptide’s interaction with dopaminergic circuits makes it relevant for studies of reward processing, incentive motivation, and behavioral activation.
Endocrine and Metabolic Research
Given MC3R and MC4R involvement in energy homeostasis, PT-141 serves as a research tool for investigating metabolic regulation pathways.
Female Sexual Dysfunction Research
PT-141 has been extensively studied in the context of hypoactive sexual desire disorder (HSDD). In 2019, the FDA approved bremelanotide (Vyleesi) for treating HSDD in premenopausal women based on clinical trial data .
Male Erectile Function Research
Research has examined PT-141’s effects on erectile activity. A clinical study evaluating co-administration of PT-141 with sildenafil showed enhanced duration of erectile activity compared to sildenafil alone .
Product Specifications
Chemical Properties
| Parameter | Specification |
|---|---|
| CAS Number | 189691-06-3 |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.20 g/mol |
| Synonyms | Bremelanotide, PT141, Rekynda, Vyleesi |
| Sequence | Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH |
| Purity | ≥98% by HPLC |
| Appearance | White lyophilized powder |
| Salt Form | Acetate or TFA salt |
Storage and Stability
| Parameter | Specification |
|---|---|
| Lyophilized Storage | -20°C for up to 12 months |
| Reconstituted Storage | 2-8°C for 2-7 days |
| Long-term Reconstituted | -20°C with carrier protein (0.1% HSA or BSA) |
| Freeze-Thaw Cycles | Avoid repeated freeze-thawing |
Solubility Profile
| Solvent | Solubility |
|---|---|
| Sterile Water (18MΩ-cm) | ≥100 µg/ml |
| Bacteriostatic Water | Recommended for reconstitution |
| DMSO | 10 mM |
Reconstitution Guidelines
For proper handling of PT-141 for research purposes:
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Allow lyophilized peptide to reach room temperature before opening
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Reconstitute with bacteriostatic water or sterile 18MΩ-cm H2O
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Aim for final concentration of 1-2 mg/ml
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Gently swirl — do not vortex or shake vigorously
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Store reconstituted solution at 2-8°C for up to 7 days
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For longer storage, aliquot and freeze at -20°C with carrier protein
Quality Assurance
At euresearchpeptides.com, every batch of PT-141 undergoes rigorous quality testing:
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HPLC Purity Analysis — ≥98% purity verified
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Mass Spectrometry (MS-ESI) — Molecular weight confirmation
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Appearance Testing — Visual inspection for consistency
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Water Content (Karl Fischer) — ≤6.0%
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Peptide Content — ≥80.0%
Handling and Safety
PT-141 is intended for laboratory research use only and is not for human consumption. Researchers must follow appropriate safety protocols:
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Use appropriate personal protective equipment (gloves, lab coat, eye protection)
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Work in a properly ventilated laboratory environment
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Dispose of materials following institutional guidelines for biological research waste
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Keep away from children and unauthorized personnel
Why Researchers Choose euresearchpeptides.com
As a premium EU-based research peptide supplier, we serve researchers across Germany, France, the Netherlands, Spain, Italy, and the United Kingdom. Our commitments include:
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EU Warehousing — Faster shipping within Europe, no international customs delays
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Independently Tested — Each batch verified by third-party analytical testing
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Competitive Pricing — Bulk discounts for research institutions
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Discreet Packaging — Professional packaging for laboratory delivery
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Compliance — Products for research use only, compliant with EU regulations
👉 Explore our complete research peptide catalog at our official homepage.
Frequently Asked Questions (FAQ)
Q1: What is PT-141 and what is it used for in research?
PT-141 (Bremelanotide) is a synthetic cyclic peptide agonist of melanocortin receptors MC3R and MC4R. Researchers use it to study neurological signaling pathways, motivational processes, and melanocortin receptor function in preclinical models .
Q2: What is the purity of your PT-141?
Our PT-141 is tested at ≥98% purity by HPLC analysis, with independent third-party verification available through Certificates of Analysis .
Q3: How should PT-141 be stored?
Lyophilized PT-141 should be stored at -20°C in a desiccated environment. Once reconstituted, store at 2-8°C and use within 7 days, or aliquot and freeze at -20°C with carrier protein .
Q4: How do I reconstitute PT-141 for research?
Reconstitute with bacteriostatic water or sterile water to achieve desired concentration (typically 1-2 mg/ml). Gently swirl to dissolve — do not vortex. Allow to fully dissolve before use .
Q5: Is PT-141 soluble in water?
Yes, PT-141 is soluble in sterile water at concentrations ≥100 µg/ml. It is also soluble in bacteriostatic water and DMSO (10 mM) .
Q6: What is the molecular weight of PT-141?
The molecular weight of PT-141 (Bremelanotide) is 1025.20 g/mol .
Q7: Do you ship PT-141 to Germany, France, and the UK?
Yes, we ship PT-141 to all EU countries including Germany, France, the Netherlands, Spain, Italy, Belgium, Austria, and the United Kingdom. Orders are dispatched from our EU warehouse.
Q8: Is PT-141 approved for human use?
No, PT-141 is sold for laboratory research use only. It is not approved for human consumption, therapeutic use, or as a drug. The FDA-approved formulation (Vyleesi) is a pharmaceutical product with different regulatory status .
Q9: What is the difference between PT-141 and Melanotan II?
PT-141 (Bremelanotide) is a deaminated derivative and metabolite of Melanotan II. While both activate melanocortin receptors, PT-141 was developed specifically for research into neurological signaling and motivational pathways, whereas Melanotan II is primarily studied for melanogenesis .
Q10: How long does PT-141 remain stable after reconstitution?
Reconstituted PT-141 remains stable at 2-8°C for 2-7 days. For extended storage beyond 7 days, freeze at -20°C with the addition of a carrier protein (0.1% HSA or BSA) and avoid repeated freeze-thaw cycles .
Q11: Can I buy PT-141 in bulk quantities?
Yes, we offer bulk quantities of PT-141 for research institutions and laboratories. Please contact our sales team for bulk pricing on 25mg, 50mg, 100mg, and larger sizes.
Q12: What testing is performed on your PT-141?
Each batch undergoes HPLC purity analysis, mass spectrometry (MS-ESI), appearance testing, water content analysis (Karl Fischer), and peptide content verification .
Q13: Is PT-141 stable at room temperature?
Lyophilized PT-141 is stable at room temperature for up to 3 weeks but should be stored desiccated below -18°C for long-term preservation .
Q14: What receptors does PT-141 target?
PT-141 is a non-selective melanocortin receptor agonist with binding affinity for MC1R (Ki=0.17 nM), MC4R (Ki=0.24 nM), MC3R (Ki=2.1 nM), and MC5R (Ki=6.3 nM) .
Q15: Do you provide Certificates of Analysis?
Yes, each batch of PT-141 includes a Certificate of Analysis (COA) with HPLC purity data and mass spectrometry verification .
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